There, the ions undergo oxidation (their negatively charged electrons are removed). Iodide ions then move to the lumen of the follicle cells that border the colloid.As a result, the concentration of iodide ions “trapped” in the follicular cells is many times higher than the concentration in the bloodstream. Binding of TSH to its receptors in the follicle cells of the thyroid gland causes the cells to actively transport iodide ions (I –) across their cell membrane, from the bloodstream into the cytosol.The following steps outline the hormones’ assembly: ![]() ![]() Hormones are produced in the colloid when atoms of the mineral iodine attach to a glycoprotein, called thyroglobulin, that is secreted into the colloid by the follicle cells. Synthesis and Release of Thyroid Hormones
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